the interferon – Communicable Diseases Research

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells

Article

Published on 2022-10-262022-11-15
Journal: mBio
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, 치료기술,

Factors influencing the SARS-CoV-2 infection and vaccination induced immune response in rheumatoid arthritis

Article

Published on 2022-10-122022-11-15
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제,

[키워드] addition age anti-CD20 therapy anti-S anti-S antibody anti-SARS-CoV-2 antibodies antibody Antibody Response BNT162b2 cell-mediated response Cellular immune response cellular immune responses ChAdOx1 Concentration Corona covariate adjustment COVID-19 COVID-19 vaccine declined dependent on DMARD (disease-modifying antirheumatic drug treatment) domains dose enrolled Factor healthy controls humoral IL-6 inhibitor immune response Infection inhibited investigated IQR magnitude median time mRNA-1273 Patient patients patients treated peptides positive patient reduced respiratory rheumatoid arthritis RNA RNA vaccine SARS-CoV-2 significant effect significantly Specific specific antibodies specific antibody subject T-cell T-cell Response targeted therapy the healthy the interferon the SARS-CoV-2 the vaccine therapy vaccination vaccination. Vaccine variables was measured were infected
[DOI] 10.3389/fimmu.2022.960001 PMC 바로가기

Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19

Research article

Published on 2022-10-012022-10-05
Journal: Computers in biology and medicine
[Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication
[DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article

Innate Immune Response and Inflammasome Activation During SARS-CoV-2 Infection

Article

Published on 2022-10-012022-11-15
Journal: Inflammation
[Category] COVID19(2023년), SARS, 변종, 진단, 치료제,

[키워드] Activation Antiviral characterized Clinical outcome COVID-19 COVID-19 outbreak Defense develop drug Effect evade flexibility Genome human pathogen IL-18 IL-1β IL-6 immune immune response immunopathology implicated IMPROVE Infection infective Inflammasome inflammasome pathway inflammatory disease inhibiting Innate innate immune response innate immune system interferon Intervention mutant strain NLRP3 novel coronavirus SARS-CoV-2 pandemic pathology Predictive preventive measure pro-inflammatory cytokine promote protective role public health receptor Replication response responsible RNA virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 shown the interferon treating COVID-19 Trigger urgent investigation vaccine candidate vaccine candidates vaccine for COVID-19 vaccine.. viral disease viral evolution virus viruses
[DOI] 10.1007/s10753-022-01651-y PMC 바로가기

Singularity and Commonality in Response to SARS-CoV-2 in Lung and Colon Cell Models

Article

Published on 2022-09-092022-11-15
Journal: International Journal of Molecular Sciences
[Category] SARS, 치료제,

[키워드] addressed Analysis Antiviral APOBEC APOBEC3G APOBECs approach both virus Caco-2 Caco-2 cell Caco-2 cells Calu-3 Calu-3 cell Calu-3 cell line Cell cell line cellular cellular response Colon commonality Course COVID-19 dataset determine differentially expressed gene disease Diseases epithelial cell events Evidence expressed genes expression pattern Factors feature gastrointestinal tract gene expression level gene signatures host response intrinsic liver lung lung; manifestation Model molecular outcome Pathomechanism Pathways performed Perturbation provide question Research Respiratory system response SARS-CoV SARS-CoV-2 similarity Systems biology systems biology. the interferon tissue expression transcriptomic translational unique
[DOI] 10.3390/ijms231810451 PMC 바로가기

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

심각하거나 치명적인 COVID-19에 대한 숙주 유전자 변이 및 감수성의 임상적 의미

Review

Published on 2022-08-192022-09-11
Journal: Genome Medicine
[Category] SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced age age allergy Asymptomatic disease clinical clinical implications Clinical management clinical picture Comorbidities convergence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deficiency develop Effects expected Factor Genetic genetic finding genetic screening Genetic variant Genetic variation healthy individual heterogeneous Host host genetics human immune response IFN-I Immunity implication indicate Infectious disease interferon Male sex malignancies manifestation Mendelian disorder Mendelian disorders modulate pandemic pathogenic variant pathway Pathways Patient Pneumonia predisposition Prevalence rare variant Rare variants risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe manifestations of COVID-19 shown susceptibility susceptibility loci the interferon TLR7 virus X-linked
[DOI] 10.1186/s13073-022-01100-3 PMC 바로가기 [Article Type] Review

Interferon resistance of emerging SARS-CoV-2 variants

새로운 SARS-CoV-2 변이체의 인터페론 내성

Article

Published on 2022-08-092022-09-11
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료제,

[키워드] (Alpha) (Beta) Alpha B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 Beta Course COVID-19 COVID-19 pandemic Critical driving ENhance exhibited FIVE highlight implication include infections Innate immunity interferon interferon response interferons isolates lethality limit lineages Mutation neutralizing antibody outbreak P.1 Pathogenesis potency responses SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants spike spike mutations subtype the interferon Transmissibility Treatment Vaccine variant variants variants of concern variants of concern. Viral viral gene viral genes viral lineage virus infectivity while
[DOI] 10.1073/pnas.2203760119 PMC 바로가기 [Article Type] Article

Implicating effector genes at COVID-19 GWAS loci using promoter-focused Capture-C in disease-relevant immune cell types

질병 관련 면역 세포 유형에서 프로모터 중심 Capture-C를 사용하여 COVID-19 GWAS 유전자좌에서 이펙터 유전자 관련

Article

Published on 2022-06-032022-09-11
Journal: Genome Biology
[Category] COVID19(2023년), SARS, 변종,

[키워드] Adaptive immune response approach attenuate B cell broad spectrum chromatin condition COVID COVID-19 COVID-19 disease COVID-19 disease severity Critical Critical illness death differentially expressed disease disease severity disease-associated e genes element exacerbate functional GART Genes genetic component Genome-wide association study genomic GWAS High-resolution Hospitalization human genetic variation IFNAR2 Immune cell immune cell type immune cells implicated in viral Inflammation interferon interferon response involved life-threatening limit loci magnitude Mild Moderate COVID-19 no symptom OAS1 OAS3 offer Patient PAXBP1 Replication risk SARS-CoV-2 SARS-COV-2 infection target the interferon Therapeutics TNFAIP8L1 variant viral replication
[DOI] 10.1186/s13059-022-02691-1 PMC 바로가기 [Article Type] Article

The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response

SARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다

Article

Published on 2022-05-092022-09-11
Journal: Theranostics
[Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome
[DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article

SARS-CoV-2-specific antibody and T-cell responses 1 year after infection in people recovered from COVID-19: a longitudinal cohort study

COVID-19에서 회복된 사람들의 감염 1년 후 SARS-CoV-2-특이 항체 및 T-세포 반응: 종단 코호트 연구

Article

Published on 2022-05-012022-09-11
Journal: The Lancet. Microbe
[Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술,

[키워드] Academy age analysed antibody Antibody Response antibody titres B.1.351 B.1.617.2 Beta Beta variant breadth caused center Chinese collected communicable disease Communicable Disease Diagnosis COVID-19 Critical cross-reactive cytokine cytokine profile D614G D614G variant delta variant Delta variants detect detectable discharged disease disease severity ELISA ELISPOT enrolled enzyme evaluated Follow-up Follow-up visit follow-up visits foundation humoral humoral and T-cell response ICS IFN-γ IFNγ IgA IgG antibodies IgG antibody IgM IL-2 immune immune response In-vitro individual individuals Infection initial interferon interferon γ interleukin interleukin-2 intracellular cytokine staining longitudinal cohort study magnitude Medical Research Council Medical Sciences memory memory immune response memory T-cell response memory T-cell responses microneutralisation assay natural Necrosis neutralising Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses neutralising antibody titre neutralising antibody titres no difference not disrupted participant Patient patients patients with moderate PBMC PBMCs plasma plasma sample plasma samples Protein Receptor-binding domain recovered patient recovered patients recruited reduce reduced reducing reduction Reinfection remained retained robustness SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 strain SARS-CoV-2 viral SARS-CoV-2-specific T-cell response Science severe disease spike Spike protein subset symptom severity Symptoms T-cell Response T-cell responses tested the interferon the receptor-binding domain the SARS-CoV-2 titre TNFα tumour necrosis factor Tumour Necrosis Factor α variant variants variants of concern Viral proteins viral strain viral strains Wuhan Wuhan, China
[DOI] 10.1016/S2666-5247(22)00036-2 PMC 바로가기 [Article Type] Article